B Soran, L Lowes, KM Steele (2016) “Evaluation of infants with spinal muscular atrophy using convolutional neural networks.” European Conference on Computer Vision

Peer-reviewed paper at European Conference on Computer Vision:

30-second videos from a depth camera can be used in the evaluation of infants with spinal muscular atrophy.

Experimental set-up with infant positioned below Kinect depth camera.Abstract: Spinal Muscular Atrophy is the most common genetic cause of infant death. Due to its severity, there is a need for methods for automated estimation of disease progression. In this paper we propose a Convolutional-Neural-Network (CNN) model to estimate disease progression during infants’ natural behavior. With the proposed methodology, we were able to predict each child’s score on current behavior-based clinical exams with an average per-subject error of 6.96 out of 72 points (<10 % difference), using 30-second videos in leave-one-subject-out-cross-validation setting. When simple statistics were used over 30-second video-segments to estimate a score for longer videos, we obtained an average error of 5.95 (8 % error rate). By showing promising results on a small dataset (N = 70, 2-minute samples, which were handled as 1487, 30-second video segments), our methodology demonstrates that it is possible to benefit from CNNs on small datasets by proper design and data handling choices.

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