2020 Center for Translational Muscle Research

How can we decipher human movement?

CTMR: White text on purple background, UW Center for Translational Muscle ResearchOur skeletal muscles have amazing structure. They provide elegant and efficient actuation to move and explore our worlds. But how do we understand how muscles produce movement?

Dr. Steele presents at the inaugural research symposium for the University of Washington Center for Translational Muscle Research. Her presentation shares examples for how we can use musculoskeletal simulation as a tool to connect muscle biology, dynamics, and mobility.

Slides | Transcript

MC Rosenberg, BS Banjanin, SA Burden, KM Steele (2020) “Predicting walking response to ankle exoskeleton using data driven models”

Journal Article in The Royal Society:

This work highlights the potential of data-driven models grounded in dynamical systems theory to predict complex individualized responses to ankle exoskeletons., without requiring explicit knowledge of the individual’s physiology or motor control

silhouette walking on left with purple lines and projections on right elipsoids and colored spheres

Aim: Evaluate the ability of three classes of subject-specific phase-varying (PV) models to predict kinematic and myoelectric responses to ankle exoskeletons during walking, without requiring prior knowledge of specific user characteristics.

Method: Data from 12 unimpaired adults walking with bilateral passive ankle exoskeletons were captured. PV, linear PV (LPV), and nonlinear PV (NPV) models leveraged Floquet theory to kinematics and muscle activity in response to three exoskeleton torque conditions.

Results: The LPV model’s predictions were more accurate than the PV model when predicting less than 12.5% of a stride in the future and explained 49–70% of the variance in hip, knee and ankle kinematic responses to torque. The LPV model also predicted kinematic responses with similar accuracy to the more-complex NPV model. Myoelectric responses were challenging to predict with all models, explaining at most 10% of the variance in responses.

Interpretation: This work highlights the potential of data-driven PV models to predict complex subject-specific responses to ankle exoskeletons and inform device design and control.

Elijah Kuska named TL1 scholar, 2020 Cohort

Elijah in a teal hockey jersey and black rectangular glasses smiles in front of a bright orange sunset.

We are very proud to announce that Elijah Kuska is part of a cohort of new trainees in the Institute of Translational Health Sciences (ITHS) TL1 Translational Research Training Program. This is a one-year mentored research training program in translational science in a cross-disciplinary community with training, career development, and team science skills.

Project Title: “Analyzing the complex interaction between impaired neuromuscular and musculoskeletal system to determine if gait abnormalities of children with cerebral palsy are advantageous”. Congratulations Elijah!