2020 Center for Translational Muscle Research

How can we decipher human movement?

CTMR: White text on purple background, UW Center for Translational Muscle ResearchOur skeletal muscles have amazing structure. They provide elegant and efficient actuation to move and explore our worlds. But how do we understand how muscles produce movement?

Dr. Steele presents at the inaugural research symposium for the University of Washington Center for Translational Muscle Research. Her presentation shares examples for how we can use musculoskeletal simulation as a tool to connect muscle biology, dynamics, and mobility.

Slides | Transcript

Elijah Kuska named TL1 scholar, 2020 Cohort

Elijah in a teal hockey jersey and black rectangular glasses smiles in front of a bright orange sunset.

We are very proud to announce that Elijah Kuska is part of a cohort of new trainees in the Institute of Translational Health Sciences (ITHS) TL1 Translational Research Training Program. This is a one-year mentored research training program in translational science in a cross-disciplinary community with training, career development, and team science skills.

Project Title: “Analyzing the complex interaction between impaired neuromuscular and musculoskeletal system to determine if gait abnormalities of children with cerebral palsy are advantageous”. Congratulations Elijah!

 

Nicole Zaino wins the ESMAC Best Paper award

Congratulations to Nicole Zaino for being awarded the ESMAC (European Society of Movement Analysis for Adults and Children) Best Paper Award. Nicole received this award at the 2019 ESMAC conference in Amsterdam, September 23-28, 2019 where she gave her talk: “Spasticity reduction in children with cerebral palsy is not associated with reduced energy during walking.” For more information, visit ESMAC.

Woman in formal attire standing behind a black and purple podium in front of a large presentation screen

ESMAC 2019: Award Finalists

Congratulations to Nicole Zaino and our colleague Mike Schwartz at Gillette Children’s Specialty Healthcare for both being nominated as finalists for the Best Presentation Award at the upcoming ESMAC Conference in Amsterdam. Their abstracts are among the top 16 submissions to the conference and the final award will be determined based upon their presentations.

Logo for the 2019 ESMAC meeting overlaid on a classic Amsterdam scene, bikes lined up on a bridge over a canal with historic buildings in the background.

Nicole will be presenting her research:

Spasticity reduction in children with cerebral palsy is not associated with reduced energy during walking 

Selective dorsal rhizotomy reduces spasticity, but does it also reduce energy consumption during walking? In an analysis of over 300 children with cerebral palsy, Nicole demonstrated that although rhiztomy does reduce spasticity, it does not reduce energy consumption. These results provide further evidence that spasticity is not a main contributor to elevated energy among people with cerebral palsy. You can also learn more about this study from our recent submitted manuscript, available on bioRxiv.

Mike will be presenting his research:

The effects of walking speed and age on energy consumption in children with cerebral palsy and their typically developing peers

We know that walking energy is high among people with cerebral palsy, and that energy varies with speed and age. Using retrospective data of over 300 kids with cerebral palsy and 150 typically-developing peers, Mike used a statistical model to evaluate these speed and age effects. He found that energy decreases until 8-10 years of age for kids with CP, while it remains stable beyond age 5 for typically-developing peers. Kids with CP also have a greater elevation in energy with greater walking speeds. These results are important to help quantify and understand impacts of interventions, like surgery or assistive devices, which are often done during this time period when kids are still growing and developing.

They will both be presenting in the Optimizing Energy Cost session from 11:40-12:30 on Thursday, September 26th.

Best of luck to Nicole & Mike!

Research Experience Undergraduates Present at CNT

This summer the Steele Lab had the pleasure of hosting three undergraduate researchers – Robin Yan from University of Washington, Ava Lakmazaheri from Olin College of Engineering, and Katherine Chamblin from University of Washington.

After a competitive selection process, students are offered a 10-week internship here at the University to work directly with a research lab on campus. One of the program’s final deliverables is a presentation of their work, both in podium and poster format, to members of the local and scientific community. Congratulations to Robin, Ava, and Katherine for their successful time here in the lab, and for giving polished presentations.

Group of six individuals standing shoulder to shoulder and smiling in front of white wall
REU Students with their lab mentors

Robin examined biomechanical analyses of typically developing individuals during emulation of cerebral palsy gait and Ava worked on optimizing musculoskeletal models for children with cerebral palsy.

Sun shinning down on young woman in business attire talking to another woman in front of a white and purple poster board
Katherine discussing her work with an interested student

Katherine investigated social communication patterns of children with cerebral palsy and their families after integrating an early-powered mobility device